Cell+Disease+Webquest

=Cell Disease Web-quest =

The objective is for you to explore some diseases and identify the organelles of the cell that are damaged. You will explore these diseases and answer the questions on the worksheet. At the end there are a set of case studies. You will use the information you gathered throughout the web-quest to identify the diseases the people have in each case study.

Disease 1: Tay-Sachs
1. Go to the following webpage: @http://www.ygyh.org/tay/cause.htm 2. Go through the tutorial and answer the accompanying questions on the worksheet.

Disease 2: Cystic Fibrosis
1. Go to the following webpage: http://learn.genetics.utah.edu/content/disorder...legene/cf/

2. Read and answer the accompanying questions on the worksheet.

Disease 3: Mitochondrial Disease
1. Go to the following webpage: @http://www.umdf.org/site/pp.aspx?c=8qKOJ0MvF7LUG&b=7934627

2. Go through the tutorial and answer the accompanying questions on the worksheet.

Disease 4: Friedreich’s Ataxia
1. Go to the following webpage: http://mdausa.org/sites/default/files/publicati..._P-188.pdf <span style="font-family: Arial,Helvetica,sans-serif;">2. Go through the tutorial and answer the accompanying questions on the worksheet.

<span style="font-family: Arial,Helvetica,sans-serif; line-height: 1.5;">1. Go to the following webpage: @http://www.mhhe.com/biosci/ap/foxhumphys/student/olc/h-reading10.html <span style="font-family: Arial,Helvetica,sans-serif; line-height: 1.5;">2. Go through the tutorial and answer the accompanying questions on the worksheet.

===<span style="font-family: Arial,Helvetica,sans-serif;">Directions: Determine which organelle is responsible for the disease symptoms. Write your answers on your WebQuest worksheets and provide reasons why you chose that particular organelle. Make sure you give detailed reasons for why you chose this organelle over the others. ===

<span style="font-family: Arial,Helvetica,sans-serif;">Case Study #1:
Mary is a fifty-five year old female, who arrived in the ER at 4:35 p.m. with complaints of severe fever and pain. The attending physician took blood work and revealed that there was a high concentration of oxidative enzymes in the blood such as catalase, D-amino acid oxidase, and uric acid oxidase. In addition, there were relatively high levels of fatty acids in the blood, which the physician suggested they were not being properly metabolized. A density gradient procedure found that an organelle approximately 0.5 microns in diameter was missing. The physician also diagnosed Mary with having gout in the joints in her hands and feet, a condition which is caused by the accumulation of uric acid. That same night around 11:00 p.m., Mary began to lose feeling in her lower back. The doctors performed a routine spinal tap (ST) to see if there was an infection in her cerebral spinal fluid. This test turned out to be negative; however, the attending physician did take a biopsy which revealed the nerve cells in Marys back were not producing enough myelin, a dielectric material needed for proper nervous system signaling.

<span style="font-family: Arial,Helvetica,sans-serif; font-size: 1.066em; line-height: 1.5;">Case Study #2:

<span style="font-family: Arial,Helvetica,sans-serif;">Lauren is a senior at a nearby high school. She is a good student who does her work on weekdays and likes to party on the weekends with her friends. A few months ago, Lauren developed a persistent cough that has worsened over time. She has also had trouble breathing over the past week or so. Her parents decided it was time she see a doctor and made an appointment with the family physician. Lauren arrived at the doctor's office the following day. The doctor asked her a number of questions about her health history and daily habits, including, whether or not she smoked cigarettes. Lauren responded that she started smoking cigarettes (about 2 per day) her freshman year of high school and does not intend to quit anytime soon. The doctor decided it was necessary to take a biopsy of the cells that line the bronchus (passageway to the lungs). After several days, the biopsy report has come back along with a micrograph of the bronchial cells. Lauren's cigarette smoking has badly damaged these organelles which are responsible for moving dirt and mucous up-and-out of her respiratory system. Analyze the micrograph (see "Case Study #2" image below) and determine what cell organelles have been damaged.

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<span style="font-family: Arial,Helvetica,sans-serif; font-size: 1.066em;">Case Study #3:

<span style="font-family: Arial,Helvetica,sans-serif;">Valerie is a studious 15 year old who is also a valuable member of her school's field hockey team. They are 15-1 this year and have a chance at winning the state championship. However, Valerie recently began feeling ill with noticeable signs of a high fever. After several days, her parents decided to take her to the ER and the attending physician admitted her to the hospital with an ongoing bacterial infection. After several more days, doctors are perplexed that her body is unable to fight off the infection. They decide to take a blood sample and have it sent to the lab for analysis. Lab results indicate that the vacuoles in her white blood cells are successfully trapping the bacteria. However, this organelle is not binding to the vacuoles and releasing the enzymes necessary to break down the bacterial cell walls. Identify the organelle so doctors can begin providing the proper treatment to Valerie.

<span style="font-family: Arial,Helvetica,sans-serif; font-size: 1.066em;">Case Study #4:

<span style="font-family: Arial,Helvetica,sans-serif;">Jim and Lisa have lived in the state of New Jersey most of their lives. They are both in their early 30's and recently married. They have been trying to have their first child for a number of months but Lisa has been unable to get pregnant. Recently, Jim and Lisa decided to go to their family physician to see if there may be something wrong. The physician obtained a sample of Jim's sperm cells and had it sent to a lab for microscopic analysis. After several days, the physician received a micrograph of the sperm cells and noted a structural defect in the organelle responsible for cell movement. Analyze the micrograph (see "Case Study #4" image below) and determine the organelle responsible for Jim and Lisa's inability to have a baby.

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<span style="font-family: Arial,Helvetica,sans-serif; font-size: 14px;">Case Study #5:

Olivia is a sixteen year old track star at a local school nearby. She arrived in the ER at 5:03 p.m. with complaints of extreme muscle weakness and loss of muscle coordination, particularly in her arms and legs! She told the attending physician that for the past few days, she had been pretty exhausted with little energy to do anything. Blood taken did show one particular abnormality. Her glucose levels were rather high although she was an athlete and did mention she ate carbohydrates the night before a race. However, this notion could be dismissed since she did not have a race in the past week. The doctors concurred that something else must be going on to render such high glucose levels (i.e. something was not breaking down these sugar molecules). In addition, the doctors ordered for a muscle biopsy to be performed. After viewing the tissue sample under the microscope, the doctors saw that the muscle fibers were ragged red which contained mild accumulations of glycogen and decreased activity for the enzyme cytochrome c oxidase.